Bolton-Hunter reagent (sulpho-SHPP), Pierce™

Supplier: Thermo Fisher Scientific

Synonyms: Sulfo-SHPP

PIER27712EA 522 EUR
PIER27712
Bolton-Hunter reagent (sulpho-SHPP), Pierce™
Bolton-Hunter reagent (sulpho-SHPP)

Sulpho-SHPP, sulphosuccinimidyl-3 -(4-hydroxypheynyl) propionate, also known as water-soluble Bolton-Hunter reagent, conjugates tyrosine-like functional groups to primary amines to increase the number of tyrosyl groups that can be iodinated by iodine-125 labeling procedures.


  • Iodinate before or after coupling to the molecule of interest
  • Preserves tyrosine residues that are essential for protein function or immunogenicity
  • NHS esters react efficiently with primary amino groups in pH 7 to 9 buffers to form stable amide bonds


Sulpho-SHPP is useful for introducing tyrosyl groups on proteins sensitive to small amounts of organic solvent and for labelling cell surfaces without exposing the cells to membrane permeable solvents.

Formula: C₁₃H₁₃NO₅
MW: 263,249 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00005515
CAS Number: 34071-95-9

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