Erythromycin ≥98%, powder
Supplier: MP Biomedicals
Erythromycin is a macrolide antibiotic that bind to the 50S ribosomal subunit and inhibit protein synthesis. This is an antimicrobial substance produced by the growth of certain strains of Streptomyces erythreus. It is a mixture consisting largely of erythromycin A with lesser amounts of erythromycins B and C.
Used in cell culture applications at approximately 100 mg/liter. Depending upon the strain of bacteria, erythromycin has been used between 50 and 200 mg/L to control bacterial growth. Erythromycin resistance can be induced in bacteria. Depending upon the strain of bacteria, erythromycin has been used between 50 and 200 mg/L to control bacterial growth.
Mode of Action: Inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).
Antimicrobial spectrum: Gram-negative and gram-positive bacteria.
Slightly soluble in water (~2 mg/ml); moderately soluble in ether, ethylene dichloride, amyl acetate; freely soluble in alcohols (ethanol - 50 mg/ml), acetone, chloroform, acetonitrile, ethyl acetate. Soluble in 2 M Hydrochloric acid (50 mg/ml).
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Formula:
C₃₇H₆₇NO₁₃ MW: 733,95 g/mol |
CAS Number:
114-07-8 |
Specification Test Results
| Synonyms | E- mycin; Erycin; Robimysin; Erythrocin |
| Form | White Powder |
| Storage | Store at Room Temperature (15 - 30 °C) |
| Extinction Coefficient | EM = 50 (280 nm, pH 6,3) |
| Moisture Content |
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| Optical Rotation | -71° to -78° (c=2, ethanol) |
| pH | 8,0 - 10,5 (70% aq soln) |
| pka | 8,8 |
| Potency | ≥850 μg/mg |
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