Anti-CD33 Mouse Monoclonal Antibody (Purified) [clone: C33/68]

Supplier: Biotium
BNUB0068-500 BNUB0068-100
BNUB0068-500EA 511 EUR
BNUB0068-500 BNUB0068-100
Anti-CD33 Mouse Monoclonal Antibody (Purified) [clone: C33/68]
Antibodies
Recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Type: Primary
Antigen: CD33
Clonality: Monoclonal
Clone: C33/68
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR