Anti-KRT10 Mouse Monoclonal Antibody (CF488A) [clone: LH2]

Supplier: Biotium

BNC880674-500EA 530 EUR
BNC880674-500 BNC880674-100
Anti-KRT10 Mouse Monoclonal Antibody (CF488A) [clone: LH2]
Antibodies
This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Type: Primary
Antigen: KRT10
Clonality: Monoclonal
Clone: Clone LH2
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse
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