N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide with 1% tert-butylchlorodimethylsilane

Supplier: Restek
Danger

Synonyms: N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, Silylating mixture VI, MTBSTFA + 1% TBDMSCl

35610 35608
REST35610EA 373 EUR
REST35610 REST35608
N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide with 1% tert-butylchlorodimethylsilane
N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide with 1% tert-butylchlorodimethylsilane

Silylation derivatization reagent.


  • Replace active hydrogen, reducing polarity and making the compounds more volatile
  • Increase stability of derivatives


Silylation is the most widely used derivatization procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group such as trimethylsilyl (TMS) or tert-butyldimethylsilyl (tert-BDMS). Silyl derivatives are more volatile, less polar, and more thermally stable. As a result, GC separation is improved and detection is enhanced.


Both TMS and tert-BDMS reagents are suitable for a wide variety of compounds and can be used for many GC applications. (Note that silylation reagents are generally moisture-sensitive and must be sealed to prevent deactivation.)

Formula: C₉H₁₈F₃NOSi
MW: 241.33 g/mol
MDL Number: MFCD00009671
CAS Number: 77377-52-7
UN: 2924
ADR: 3/8,II

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