Human Ghrelin

Supplier: ENZO LIFE SCIENCES

ALX157021M001 ALX157021MC05
ENZOALX157021M001EA 585 EUR
ENZOALX157021M001 ENZOALX157021MC05
Human Ghrelin
Proteins and Peptides

Endogenous GHS-R ligand


Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system.

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