Gentamicin sulphate
Supplier: MP Biomedicals
Gentamicin sulpahte is used as a selection agent (gentamicin-resistance gene) in molecular biology applications.It is used to treat many types of bacterial infections, particularly those caused by gram-negative organisms.
It causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilises the membrane, and forms holes in the cell surface. Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria.
H2O: soluble 50 mg/ml (As a stock solution. Stock solutions should be stored at −20 °C.) (Lit.)
Melting Pt:
218…237 °C |
MDL Number:
MFCD00270181 CAS Number: 1405-41-0 Merck Index: 13,04403 |
Specification Test Results
Synonyms | Garamycin; Gentamicin sulphate salt; Gentiomycin C |
Form | White powder |
Storage | Store at +4 °C |
Loss on Drying | ≤18,0 % |
Optical Rotation | 107° to +121° (10 mg/ml, water) |
pH | 3,5 - 5,5 (1 in 25, in water) |
Potency | ≥590 µg/mg |
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