Clotrimazole ≥98.0% (by TLC), Sigma-Aldrich®

Supplier: Merck
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Synonyms: 1-(2-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]imidazole

M-Clarity™ quality level = MQ200

C6019-100G C6019-25G C6019-5G
SIALC6019-100GEA 1170 EUR
SIALC6019-100G SIALC6019-25G SIALC6019-5G
Clotrimazole ≥98.0% (by TLC), Sigma-Aldrich®
Clotrimazole

Clotrimazole is a specific inhibitor of Ca²⁺ activated K⁺ channels. It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole. It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.


Cltrimazole is used to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, to induce stress granules via mitochondrial stress, for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB) and to inhibit cytochrome P450 enzyme in cell cultures.

Formula: C₂₂H₁₇ClN₂
MW: 344.84 g/mol
MDL Number: MFCD00057220
CAS Number: 23593-75-1

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Specification Test Results

λmax 261 nm
Carbon Content 75.1 - 78.2%
Nitrogen Content 7.8 - 8.4%
Purity (TLC) ≥98.0%

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