Dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine 97%

Supplier: Merck

Synonyms: 2-Dicyclohexylphosphino-2’,6’-dimethoxybiphenyl, SPhos, Dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine, 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl, 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl

M-Clarity™ quality level = MQ300

638072-1G 638072-25G 638072-5G 638072-100G 638072-500G
SIAL638072-1GEA 72.1 EUR
SIAL638072-1G SIAL638072-25G SIAL638072-5G SIAL638072-100G SIAL638072-500G
Dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine 97%
Dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine

SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) is an air-stable and electron-rich biaryl phosphine ligand. Highly universal ligand for Suzuki-Miyaura coupling, aryl chlorides, hindered biaryls, heterobiaryls.


Used for palladium catalysed Suzuki-Miyaura cross-coupling reaction between boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes, methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines and intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C. Also utilised in conjunction with palladium to form a highly active catalyst for C-N bond formation.

Formula: C₂₆H₃₅O₂P
MW: 410.53 g/mol
Melting Pt: 164...166 °C (lit.)
MDL Number: MFCD05861611
CAS Number: 657408-07-6

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Specification Test Results

Assay 97%
Appearance (Colour) White
Appearance (Form) (Powder, Crystals, Crystalline Powder, Solid, and/or Chunks) Conforms to Requirements
Infrared Spectrum Conforms to Structure
Proton NMR Spectra Conforms to Structure
Phosphorus NMR Spectra Conforms to Structure

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