Aluminon, powder, Sigma-Aldrich®
Supplier: SIGMA-ALDRICH MICROSCOPY
M-Clarity™ quality level = MQ200
Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.
Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.
Specification Test Results
Appearance (Colour) | Dark Brown to Very Dark Brown and Dark Red to Very Dark Red and Very Dark Red-Brown |
Appearance (Form) | Powder |
Solubility (Colour) 100 mg/ml in water |
Dark Red |
Water | Report Result |
Carbon Content | Report Result |
Carbon Content | Report Result |
Nitrogen Content | Report Result |
Application Test Sensitivity to Aluminium Passes Test |
Corresponds to Requirements |
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