Aluminon ACS, Sigma-Aldrich®
Supplier: SIGMA-ALDRICH MICROSCOPY
M-Clarity™ quality level = MQ300
Reagent for aluminium. Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.
Specification Test Results
Appearance (Colour) | Red to Very Dark Red and Red-Brown and Brown-Red |
Appearance (Form) | Powder or Crystals |
Infrared spectrum | Conforms to Structure |
Insoluble matter, c = 1%, Water and Dilute NH4OH | ≤0.1% |
Sensitivity Test, Sensitivty to Aluminum | Pass |
Residue on ignition (Ash) | ≤0.2% |
Solubility (Colour) c = 100 mg/ml; Water | Red to Very Dark Red and Red-Brown and Brown-Red |
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