You Searched For: 3-(4-Fluorophenylthio)butyric+acid

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Anti-FFAR2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-13536R-CY7)

Supplier: Bioss

Description: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).

UOM: 1 * 100 µl

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Sulphosuccinimidyl 4-(4-azidophenyl)butyrate

Catalog Number: (APOSBIPA115-100MG)

Supplier: Apollo Scientific

Description: Photoreactive -Primary amine reactive Water soluble

UOM: 1 * 100 mg

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Ethyl-4,4,4-trifluoro-3-(trifluoromethyl)butyrate 97%

Supplier: Apollo Scientific

Description: Ethyl-4,4,4-trifluoro-3-(trifluoromethyl)butyrate 97%

Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate

Catalog Number: (APOSOR470357-5G)

Supplier: Apollo Scientific

Description: Ethyl 3-Oxo-4-(1-Boc-4-piperidyl)butyrate

UOM: 1 * 5 g

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Methyl 4-(1,1-Dioxothiomorpholino)butyrate

Catalog Number: (APOSOR470243-1G)

Supplier: Apollo Scientific

Description: Methyl 4-(1,1-Dioxothiomorpholino)butyrate

UOM: 1 * 1 g

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Human recombinant proline-rich acidic 1 (from cells)

Catalog Number: (PRSI91-734)

Supplier: ProSci Inc.

Description: Proline-rich acidic protein 1, also known as Uterine-specific proline-rich acidic protein, UPA and PRAP1, is a secreted protein. PRAP1 is abundantly expressed in the epithelial cells of the liver, kidney, gastrointestinal tract and cervix. PRAP1 is up-regulated by butyrate, trichostatin A and 5'-aza-2' deoxycytidine. PRAP1 may play an important role in maintaining normal growth homeostasis in epithelial cells. PRAP1 is suppressed through epigenetic mechanisms involving histone deacetylation and methylation. PRAP1 has been shown to cause cell growth inhibition in cancer cell lines.

UOM: 1 * 50 µG

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