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Image Unavailable-BOSSBS-7834R-CY3

Anti-CDCA8 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-7834R-CY3)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7834R-A750

Anti-CDCA8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-7834R-A750)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7834R-A350

Anti-CDCA8 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-7834R-A350)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7834R-A555

Anti-CDCA8 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-7834R-A555)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7834R-A647

Anti-CDCA8 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-7834R-A647)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Product Image-MFLX31603-05

CPC® ChemQuik® Quick-Disconnect Fittings, Panel-Mount Coupling Bodies

Catalog Number: (MFLX31603-05)
Supplier: Avantor Fluid Handling
Description: All plastic construction for high-purity use.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-7834R-A488

Anti-CDCA8 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-7834R-A488)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7834R-HRP

Anti-CDCA8 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-7834R-HRP)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7834R-A680

Anti-CDCA8 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-7834R-A680)
Supplier: Bioss
Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
UOM: 1 * 100 µl
Product Image-MFLX31311-64

CPC® Plastic Quick-Disconnect Fittings, Sealing Caps

Supplier: Avantor Fluid Handling
Description: Fittings connect in a snap.

Certificates

Image Unavailable-BOSSBS-2445R-A350

Anti-AURKB Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-2445R-A350)
Supplier: Bioss
Description: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515). AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively). A positive feedback between GSG2 and AURKB contributes to CPC localization. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity. Key regulator of active promoters in resting B- and T-lymphocytes.
UOM: 1 * 100 µl
Product Image-MFLX20202-72

CPC® AseptiQuik® W Genderless Aseptic Connectors

Supplier: Avantor Fluid Handling
Description: Provide easy, secure sterile connections even in nonsterile environments now in newly engineered larger sizes.

Product Image-MFLX31303-01

CPC® High-Flow Quick-Disconnect Fittings, Threaded Bodies

Supplier: Avantor Fluid Handling
Description: No more leaks - valved couplings automatically shut off flow.

Product Image-MFLX06364-30

CPC® Quick-Disconnect Fittings, Compression Inserts

Supplier: Avantor Fluid Handling
Description: No more struggling - just press thumb latch.

Certificates

Product Image-MFLX31404-69BLK

CPC® Metal Quick-Disconnect Fittings, Compression Inserts

Supplier: Avantor Fluid Handling
Description: Convenience of a quick-disconnect in pressure and vacuum applications.

Product Image-MFLX20002-89

CPC® AseptiQuik-C® Hose Barb Connectors, Standard Flow

Supplier: Avantor Fluid Handling
Description: Provide easy, secure sterile connections even in nonsterile environments.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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