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Catalog Number: (BOSSBS-0665R-CY5.5)
Supplier: Bioss
Description: Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 3 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).
UOM: 1 * 100 µl


Supplier: Thermo Fisher Scientific
Description: Multi-Element Standard, Alkali Metals, Plasma Standard Solution, Ba,Be,Ca,Cs,K,Li,Mg,Na,Rb,Sr, 100 μg/ml, Specpure®, Matrix: 5% HNO₃, Application: ICP standards
Catalog Number: (BOSSBS-11188R-FITC)
Supplier: Bioss
Description: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-11188R)
Supplier: Bioss
Description: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.
UOM: 1 * 100 µl


Supplier: asecos
Description: Spill Control, Joining element, 2470×45 mm

Supplier: VWR Chemicals
Description: 15 components: Al 50 ug/ml, As 50 ug/ml, Ba 50 ug/ml, Cd 50 ug/ml, Co 50 ug/ml, Cr 50 ug/ml, Cu 50 ug/ml, Mn 50 ug/ml, Mo 50 ug/ml, Ni 50 ug/ml, Pb 50 ug/ml, Se 50 ug/ml, Sr 50 ug/ml, Zn 50 ug/ml, K 500 ug/ml in 5% HNO₃
Catalog Number: (BOSSBS-13224R-A750)
Supplier: Bioss
Description: FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
UOM: 1 * 100 µl


Catalog Number: (WS32-1L)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: Popular hematology stain used for differentially staining the cellular elements of blood. For dip, rack, and batch staining techniques.
UOM: 1 * 1 L


Supplier: S.C.A.T.
Description: Place the collecting container/canister where needed; the pipe system can be exactly configured to suit specific needs.

Catalog Number: (USBII8615-75D)
Supplier: US Biological
Description: Anti-Iron Responsive Element Binding Protein 2 Mouse Monoclonal Antibody [clone: 10E57]
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-10235R-FITC)
Supplier: Bioss
Description: Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-10235R-A555)
Supplier: Bioss
Description: Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8452R-CY3)
Supplier: Bioss
Description: SNAPC3 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC3 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAPC3 recruits TBP and BRF2 to the U6 snRNA TATA box.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-5190R-CY5)
Supplier: Bioss
Description: ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene).
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8452R-A680)
Supplier: Bioss
Description: SNAPC3 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC3 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAPC3 recruits TBP and BRF2 to the U6 snRNA TATA box.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-8452R-A750)
Supplier: Bioss
Description: SNAPC3 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC3 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAPC3 recruits TBP and BRF2 to the U6 snRNA TATA box.
UOM: 1 * 100 µl


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
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