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Image Unavailable-BOSSBS-1135R-FITC

Anti-SRC Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-1135R-FITC)
Supplier: Bioss
Description: c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1135R-CY3

Anti-SRC Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-1135R-CY3)
Supplier: Bioss
Description: c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
UOM: 1 * 100 µl
Product Image-SIMPM473-60

Microarray molds kits, T-Sue™

Supplier: Simport Scientific
Description: T-Sue™ Microarray mold, enabling tissues from many donor blocks to be arrayed on a single slide.

Product Image-RPK0325

Microarray hybridisation solution v2.0

Catalog Number: (RPK0325)
Supplier: Cytiva
Description: Microarray hybridisation solution version 2.0, for highly reproducible microarray results.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-1135R-HRP

Anti-SRC Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-1135R-HRP)
Supplier: Bioss
Description: c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1135R-A555

Anti-SRC Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-1135R-A555)
Supplier: Bioss
Description: c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
UOM: 1 * 100 µl
Product Image-EDVO235

Experimentation kits, DNA/RNA microarrays

Catalog Number: (EDVO235)
Supplier: EDVOTEK
Description: Microarray technology allows scientists to screen large numbers of samples in one assay. This technology allows high-throughput screening of small samples and allows comparisons to be made between healthy and unhealthy tissues. In this experiment, students apply simulated DNA and RNA samples to a membrane to screen for positive and negative samples.
UOM: 1 * 1 KIT
Product Image-732-4825

Microarray slides, Gene Frame® II

Supplier: Thermo Fisher Scientific
Description: Microarray slides for <i>in situ</i> hybridisation and amplification with standard microscope slides.

Image Unavailable-ANTIA84635-100

Anti-CTAG1B Goat Polyclonal Antibody

Catalog Number: (ANTIA84635-100)
Supplier: ANTIBODIES.COM
Description: Goat polyclonal antibody to CTAG1B for ELISA, IF, flow cytometry and Microarray with samples derived from human.
UOM: 1 * 100 µG

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Product Image-ANTIA304801-100

Anti-Nav1.7 Mouse Monoclonal Antibody [clone: N68/6]

Catalog Number: (ANTIA304801-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [N68/6] antibody to Nav1.7 for WB, IHC, ICC/IF, IP and antibody microarray with samples derived from human, mouse, rat and hamster.
UOM: 1 * 100 µG

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Product Image-ANTIA304815-100

Anti-SHANK1 Mouse Monoclonal Antibody [clone: N22/21]

Catalog Number: (ANTIA304815-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [N22/21] antibody to SHANK1 for WB, IHC and antibody microarray with samples derived from human, mouse and rat.
UOM: 1 * 100 µG

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Product Image-ANTIA305021-100

Anti-KCNQ4 Mouse Monoclonal Antibody [clone: N43/6]

Catalog Number: (ANTIA305021-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [N43/6] antibody to KCNQ4 for WB, IHC, ICC/IF, IP and antibody microarray with samples derived from human, mouse and rat.
UOM: 1 * 100 µG

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Product Image-ANTIA304814-100

Anti-SHANK2 Mouse Monoclonal Antibody [Clone: N23b/6]

Catalog Number: (ANTIA304814-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [N23b/6] antibody to SHANK2 for WB, IHC, IP, ICC/IF and antibody microarray with samples derived from human, mouse and rat.
UOM: 1 * 100 µG

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Product Image-ANTIA304805-100

Anti-TSP23 Mouse Monoclonal Antibody [clone: Tsp232A]

Catalog Number: (ANTIA304805-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [Tsp232A] antibody to TSP23 for WB, IHC and antibody microarray with samples derived from human and mouse.
UOM: 1 * 100 µG

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Product Image-ANTIA304793-100

Anti-DMPO Mouse Monoclonal Antibody [clone: N1664A]

Catalog Number: (ANTIA304793-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [N1664A] antibody to DMPO for WB, IHC, ICC/IF, IP, ELISA and antibody microarray with samples derived from species independent.
UOM: 1 * 100 µG

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Product Image-ANTIA304821-100

Anti-TRPM7 Mouse Monoclonal Antibody [clone: S74]

Catalog Number: (ANTIA304821-100)
Supplier: ANTIBODIES.COM
Description: Mouse monoclonal [S74] antibody to TRPM7 for WB, IHC, ICC/IF and antibody microarray with samples derived from human, mouse and rat.
UOM: 1 * 100 µG

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
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The original product is no longer available. The replacement shown is available.
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