You Searched For: N-Hydroxysulphosuccinimide

Supplier: Apollo Scientific

Description: Forms amine reactive peptides

New Product

Catalog Number: (BC12)

Supplier: G-Biosciences

Description: m-Maleimidobenzoyl-N-hydroxysulfosuccinimide esterHeterobifunctional Cross Linker

UOM: 1 * 100 mg

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Catalog Number: (BC97)

Supplier: G-Biosciences

Description: Sulpho-NHS reacts primarily with primary amines to convert carboxyl groups to amine reactive sulfo-NHS esters. It is ideal for cross-linking, chemical labelling and solid support immobilisation. It is used to generate amine reactive esters from carboxylate groups and is primarily used to increase the efficiency of the carbodiimide EDC cross-linking. EDC reactions do not require Sulpho-NHS; however, its presence greatly enhances cross-linking efficiency and allows for a two-step process. EDC reacts with a carboxylate group to form an active ester, which is subject to rapid hydrolysis in aqueous buffers. The Sulfo-NHS increases the stability of the active intermediate and the resulting coupled product is identical to EDC reactions without sulpho-NHS.

UOM: 1 * 500 mg

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Supplier: Apollo Scientific

Description: Sulpho-NHS (N-Hydroxysulphosuccinimide sodium salt) 99%

Supplier: Thermo Scientific

Description: Sulpho-NHS (N-Hydroxysulphosuccinimide sodium salt) 97%

MSDS Certificates

Catalog Number: (APOSBICL203-100MG)

Supplier: Apollo Scientific

Description: Primary amine and sulphhydryl reactive -Water soluble

UOM: 1 * 100 mg

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Supplier: Thermo Scientific

Description: Sulpho-NHS (N-Hydroxysulphosuccinimide sodium salt) 95%

MSDS

Catalog Number: (PIERA39269)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Sulfo-NHS, No-Weigh Format is a chemical modification reagent for converting carboxyl groups to amine-reactive NHS esters for bioconjugation, crosslinking, labeling and immobilization methods.

UOM: 1 * 20 mg

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Catalog Number: (PIER22312)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Sulfo-MBS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short aromatic spacer arm (7.3 angstroms).

UOM: 1 * 50 mg

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Supplier: Thermo Fisher Scientific

Description: Pierce™ Sulfo-NHS (N-hydroxysulfosuccinimide) is a chemical modification reagent for converting carboxyl groups to amine-reactive NHS esters for bioconjugation, crosslinking, labeling and immobilisation methods.

Certificates

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Premium Grade Sulfo-NHS is our highest quality formulation of this N-hydroxysuccinimide chemical modification reagent, specially characterized for applications where product integrity and risk minimization are paramount.

Supplier: Merck

Description: N-Hydroxysulfosuccinimide sodium salt is a water-soluble sulfonated analog of N-hydroxysuccinimide. It can undergo a coupling reaction with carboxylic acids in the presence of carbodiimides such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC) to form hydrophilic N-hydroxysulfosuccinimide active esters. These esters are useful in protein cross-linking experiments.

Certificates

Catalog Number: (SIAL803227-50MG)

Supplier: Merck

Description: MBS and its water-soluble analog Sulfo-MBS are heterobifunctional crosslinkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these crosslinkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneously with the maleimide (sulfhydryl-targeted) reaction.

UOM: 1 * 50 mg

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