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Product Image-PRSI96-695

Human recombinant sirpa2 (from HEK293 cells)

Catalog Number: (PRSI96-695)
Supplier: ProSci Inc.
Description: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
UOM: 1 * 100 µG
Product Image-PRSI96-694

Human recombinant sirpa1 (from HEK293 cells)

Catalog Number: (PRSI96-694)
Supplier: ProSci Inc.
Description: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
UOM: 1 * 100 µG
Product Image-STMC100-0932

Human Recombinant Leptin

Catalog Number: (STMC100-0932)
Supplier: STEMCELL Technologies
Description: Leptin is a protein produced from the ob gene or lep gene, and acts as both a hormone involved in metabolic function as well as a proinflammatory cytokine by inducing Th1 immune responses (Dunn <i>et al.</i>; La Cava; Newman and Gonzalez-Perez). Leptin is a member of the gp130 family of cytokines and is known to be correlated with obesity (Dixit <i>et al.</i>; Dunn <i>et al.</i>). Leptin can both promote osteogenesis via osteoblast receptors and inhibit it through its actions on the hypothalamus (Figenschau <i>et al.</i>). It is a small, non-glycosylated protein with a highly conserved sequence between species. Leptin binds to the leptin receptor OB-R, which exists in six isoforms in humans and can activate various Janus kinase (JAK) and downstream pathways (Dunn <i>et al.</i>; Münzberg and Morrison; Newman and Gonzalez-Perez). For example, the binding of leptin to LepRb receptor activates JAK2, which leads to the phosphorylation of both JAK2 and the LepRb receptor, with three separate residues on the receptor triggering signaling pathways for SHP-2, STAT5, and STAT3 (Dunn <i>et al.</i>; Münzberg and Morrison). In addition to its effects on mature immune cells, other studies have suggested impacts on other cell types, with activities such as inducing cell proliferation and morphological differentiation in hematopoietic cell lines, chondrocytes, and hepatic cells (Figenschau <i>et al.</i>; Gainsford <i>et al.</i>; Santos-Alvarez <i>et al.</i>; Wang <i>et al.</i>).
UOM: 1 * 2 mg
Image Unavailable-ABCAAB206309-96

MOUSE SHP-2 ELISA KIT (PTPN11) SIMPLESTE 1 * 96 Tests

Catalog Number: (ABCAAB206309-96)
Supplier: Abcam
Description: MOUSE SHP-2 ELISA KIT (PTPN11) SIMPLESTE 1 * 96 Tests
UOM: 1 * 96 Tests
Image Unavailable-BOSSBS-1233R-A680

SHP-2/PTPN11 POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

Catalog Number: (BOSSBS-1233R-A680)
Supplier: Bioss
Description: SHP-2/PTPN11 POLYCLONAL ANTIBODY, ALEXA FLUOR® 680 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1233R-A750

SHP-2/PTPN11 POLYCLONAL ANTIBODY, ALEXA FLUOR® 750 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl

Catalog Number: (BOSSBS-1233R-A750)
Supplier: Bioss
Description: SHP-2/PTPN11 POLYCLONAL ANTIBODY, ALEXA FLUOR® 750 CONJUGATED, HOST: RABBIT, CROSS REACTIVE SPECIES: HUMAN, MOUSE, RAT, APPLICATION: IF(IHC-P), CONCENTRATION: 1UG/UL, VOLUME: 100UL 1 * 100 µl
UOM: 1 * 100 µl
Image Unavailable-ABCAAB252906-1

Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free 1 * 1 mg

Catalog Number: (ABCAAB252906-1)
Supplier: Abcam
Description: Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free 1 * 1 mg
UOM: 1 * 1 mg
Image Unavailable-ABCAAB242578-100

Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free Capture 1 * 100 µG

Catalog Number: (ABCAAB242578-100)
Supplier: Abcam
Description: Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free Capture 1 * 100 µG
UOM: 1 * 100 µG
Image Unavailable-ABCAAB252906-100

Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free 1 * 100 µG

Catalog Number: (ABCAAB252906-100)
Supplier: Abcam
Description: Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free 1 * 100 µG
UOM: 1 * 100 µG
Image Unavailable-ABCAAB242578-1

Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free Capture 1 * 1 mg

Catalog Number: (ABCAAB242578-1)
Supplier: Abcam
Description: Rabbit monoclonal EPR17828-47 to SHP2 - BSA and Azide free Capture 1 * 1 mg
UOM: 1 * 1 mg
Image Unavailable-ABCAAB187039-100

Rabbit monoclonal EPR17828-47 to SHP2 1 * 100 µl

Catalog Number: (ABCAAB187039-100)
Supplier: Abcam
Description: Rabbit monoclonal EPR17828-47 to SHP2 1 * 100 µl
UOM: 1 * 100 µl
Image Unavailable-SHPS5005-10000-159

coupling G 3/8 - G 1/4 1 * 1 items

Catalog Number: (SHPS5005-10000-159)
Supplier: SHP Steriltechnik
Description: coupling G 3/8 - G 1/4 1 * 1 items
UOM: 1 * 1 items
Image Unavailable-SHPS5005-10000-029

FOOT 1 * 1 items

Catalog Number: (SHPS5005-10000-029)
Supplier: SHP Steriltechnik
Description: FOOT 1 * 1 items
UOM: 1 * 1 items
Image Unavailable-SHPS5005-10000-149

T-iron R 1/4 i/a/l 1 * 1 items

Catalog Number: (SHPS5005-10000-149)
Supplier: SHP Steriltechnik
Description: T-iron R 1/4 i/a/l 1 * 1 items
UOM: 1 * 1 items
Image Unavailable-SHPS290000000041

T iron 1 * 1 items

Catalog Number: (SHPS290000000041)
Supplier: SHP Steriltechnik
Description: T iron 1 * 1 items
UOM: 1 * 1 items
Image Unavailable-SHPS290000000161

Bearing 1 * 1 items

Catalog Number: (SHPS290000000161)
Supplier: SHP Steriltechnik
Description: Bearing 1 * 1 items
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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