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Tyrphostin AG-126

Supplier: Apollo Scientific
Description: MAPK/ERK Signalling Pathway

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Tyrphostin AG-126 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

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Tyrphostin AG 527 ≥98% (by HPLC)

Catalog Number: (ENZOALX270141M025)
Supplier: ENZO LIFE SCIENCES
Description: Tyrphostin AG 527 ≥98% (by HPLC)
UOM: 1 * 25 mg

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Tyrphostin AG 490 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

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Tyrphostin 1 95%

Supplier: Apollo Scientific
Description: Tyrphostin 1 95%

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Tyrphostin AG 1024 ≥98% (by HPLC and UV method)

Supplier: ENZO LIFE SCIENCES
Description: Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

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Tyrphostin B7 ≥99% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

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Tyrphostin AG 183 ≥99%

Catalog Number: (ENZOBMLEI1890005)
Supplier: ENZO LIFE SCIENCES
Description: A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate.
UOM: 1 * 5 mg

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Tyrphostin AG 1478 free base 99+%

Supplier: Apollo Scientific
Description: Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 uM). Eur. J. Biochem. 225: 1047-1053 (1994).

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Tyrphostin AG 1295 ≥98%

Catalog Number: (ENZOALX270035M005)
Supplier: ENZO LIFE SCIENCES
Description: Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
UOM: 1 * 5 mg

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Tyrphostin AG 1478 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
Description: EGFR inhibitor

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Tyrphostin AG-1296 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

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Tyrphostin A25 ≥99%

Catalog Number: (ENZOBMLEI1870005)
Supplier: ENZO LIFE SCIENCES
Description: A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).
UOM: 1 * 5 mg

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AG-879 ≥99%

Supplier: ENZO LIFE SCIENCES
Description: NGF receptor inhibitor

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Tyrphostin 1 ≥99%

Supplier: ENZO LIFE SCIENCES
Description: An inactive tyrphostin, which may be used as a negative control.

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AG-494 ≥98% (by TLC)

Catalog Number: (ENZOBMLEI2280010)
Supplier: ENZO LIFE SCIENCES
Description: AG-494 is a member of the tyrphostin family of tyrosine kinase inhibitors and is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 µM) and EGF-dependent cell growth (IC50=6 µM). It selectively inhibits HER1 (EGF receptor) vs. HER1-2 receptor autophosphorylation (HER1: IC50=1.1 µM; HER1-2: IC50=45 µM). HER1-2 is a chimeric receptor consisting of the external HER1 domain fused to an internal HER2 domain. Blocks CDK2 activation and causescells to arrest at late G1 and during S phase.
UOM: 1 * 10 mg

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
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Dual use goods can only be delivered within the European Union.
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