You Searched For: WYE-125132

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WYE-125132 ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Description: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

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WYE-125132 ≥98%, crystalline solid

Supplier: Cayman Chemical

Description: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.

WYE-23 ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Description: Cell-permeable, potent, selective, and ATP-competitive mTOR inhibitor.

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WYE-28 ≥97% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Description: Cell-permeable, potent, selective, and ATP-competitive mTOR inhibitor.

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Pure-Fit® SIB® Smooth Inner Bore Connector Systems

Supplier: Saint Gobain Life Sciences

Description: Pure-Fit SIB eliminates entrapment and leak points that can occur with traditional assembly systems. The unique internal design eliminates voids or dead space that can lead to turbulence or stagnation of fluid flow creating the potential for bacterial growth.