You Searched For: ProSci Inc.

Catalog Number: (PRSI5661)

Supplier: ProSci Inc.

Description: LYRM2 Antibody: The Lyr motif found in the LYR-motif containing protein family is similar to that found in the sacchromyces cerevisiae protein ISD11, an iron-sulfur protein in the mitochondria that is thought to play a role in iron homeostasis. No known function has been assigned to LYRM2, although LYRM1 is thought to be involved in preadipocyte progression and LYRM3 has been suggested to be a candidate gene for the branchio-oto-renal (BOR) syndrome.

UOM: 1 * 100 µG

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Catalog Number: (PRSI6003P)

Supplier: ProSci Inc.

Description: ZNF346 peptide is used for blocking the activity of ZNF346 antibody.

UOM: 1 * 50 µG

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Catalog Number: (PRSI28-730)

Supplier: ProSci Inc.

Description: EDF1 encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.

UOM: 1 * 100 µG

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Catalog Number: (PRSI28-744)

Supplier: ProSci Inc.

Description: NSBP1 binds specifically to nuclear core particles and acts as a transcriptional activator.

UOM: 1 * 50 µG

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Catalog Number: (PRSI7167)

Supplier: ProSci Inc.

Description: JAKMIP2 Antibody: JAKMIP2, also known as neuroendocrine long coiled-coil protein 1 (NECC1), is a member of the JAKMIP family of proteins whose members are thought play a role in JAK1 signaling and the regulation of microtubule cytoskeleton rearrangements. JAKMIP2 is expressed predominantly in neuronal cells but unlike JAKMIP1, JAKMIP2 localizes to the Golgi complex. It has been suggested that JAKMIP2 may play important roles in the control of the regulated secretory pathway.

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-827)

Supplier: ProSci Inc.

Description: SOX3 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.

UOM: 1 * 50 µG

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Catalog Number: (PRSI27-825)

Supplier: ProSci Inc.

Description: SMARCC1 is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-831)

Supplier: ProSci Inc.

Description: Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The SOX12 gene encodes a protein that was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.

UOM: 1 * 50 µG

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Catalog Number: (PRSI45-439)

Supplier: ProSci Inc.

Description: Anti-CXCR3 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-823)

Supplier: ProSci Inc.

Description: ZNF447 contains 1 SCAN box domain and 2 C2H2-type zinc fingers. It belongs to the kruppel C2H2-type zinc-finger protein family and may be involved in transcriptional regulation.

UOM: 1 * 100 µG

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Catalog Number: (PRSI45-438)

Supplier: ProSci Inc.

Description: Anti-CTDSP1 Goat Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (PRSI6821)

Supplier: ProSci Inc.

Description: PRC1 Antibody: PRC1 (Protein Regulator of Cytokinesis 1) is a key regulator of cytokinesis and has been identified as a substrate for several cyclin-dependent kinases (CDKs). High levels of PRC1 expression occurs during S and G2/M and drops dramatically after mitosis exit and G1 entry. It is located in the nucleus during interphase and binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis.

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-919)

Supplier: ProSci Inc.

Description: NR1I3 is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members.

UOM: 1 * 100 µG

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Catalog Number: (PRSI27-910)

Supplier: ProSci Inc.

Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.

UOM: 1 * 100 µG

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Catalog Number: (PRSI6801)

Supplier: ProSci Inc.

Description: TFEB Antibody: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.

UOM: 1 * 100 µG

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Catalog Number: (PRSI6803)

Supplier: ProSci Inc.

Description: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.

UOM: 1 * 100 µG

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