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Supplier: Tonbo Biosciences

Description: The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells. The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

Supplier: Tonbo Biosciences

Description: The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry.

Catalog Number: (25-4321-U100)

Supplier: Tonbo Biosciences

Description: The A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin binds to TNP (trinitrophenol), a hapten not expressed on mouse or human cells. It is used as an isotype control for rat IgG2a antibodies.

UOM: 1 * 100 µG

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Catalog Number: (20-4888-U100)

Supplier: Tonbo Biosciences

Description: The PIP immunoglobulin is useful as an isotype-matched control. The PIP immunolglobulin is specific for Glutathione S-transferase and can be used as an isotype control for Armenian Hamster IgG antibodies.

UOM: 1 * 100 µG

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Supplier: Tonbo Biosciences

Description: The M1/69 antibody reacts with mouse CD24, a cell surface molecule also known as Heat Stable Antigen (HSA). CD24 is a GPI-linked glycoprotein involved in cell adhesion and is a ligand for CD62P (P-selectin). It is expressed on erthrocytes, thymocytes, peripheral lymphocytes and myeloid lineage cells. The expression of CD24 is used to delineate stages of of lymphocyte development in the bone marrow.

Catalog Number: (70-8040-M002)

Supplier: Tonbo Biosciences

Description: Goat anti-Mouse IgG (H&L) - Affinity Pure, min x w/bovine, horse, human, pig or rabbit serum protein

UOM: 1 * 2 mg

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Catalog Number: (35-8058-U500)

Supplier: Tonbo Biosciences

Description: Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate

UOM: 1 * 0,5 mg

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Catalog Number: (72-8081-M001)

Supplier: Tonbo Biosciences

Description: Goat anti-Chicken IgY (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalog Number: (50-8033-U100)

Supplier: Tonbo Biosciences

Description: Goat anti-mouse IgG (H+L), secondary antibody, SureLight® R-Phycoerythrin, 100ug

UOM: 1 * 100 µG

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Catalog Number: (35-8067-M002)

Supplier: Tonbo Biosciences

Description: Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate

UOM: 1 * 2 mg

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Catalog Number: (72-8082-M001)

Supplier: Tonbo Biosciences

Description: Donkey anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalog Number: (30-8080-M001)

Supplier: Tonbo Biosciences

Description: Donkey anti-Goat IgG (H&L) - Affinity Pure, Biotin Conjugate, min x w/human, mouse, rabbit or rat IgG

UOM: 1 * 1 mg

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Catalog Number: (72-8095-M001)

Supplier: Tonbo Biosciences

Description: Rabbit anti-Goat IgG (H&L) - Affinity Pure, HRP Conjugate

UOM: 1 * 1 mg

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Catalog Number: (72-8077-M001)

Supplier: Tonbo Biosciences

Description: Rabbit anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human serum proteins

UOM: 1 * 1 mg

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Supplier: Tonbo Biosciences

Description: The MF23 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is a member of the forkhead box or winged helix family of transcription factors and is expressed at constitutively high levels in Treg cells. Forced expression of Foxp3 in conventional T cells results in the upregulation of Treg associated molecules such as CD25, CTLA-4, and GITR and is sufficient to impart suppressive functional activity to these cells.

Catalog Number: (75-4301-U100)

Supplier: Tonbo Biosciences

Description: The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.

UOM: 1 * 100 µG

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