Anti-CSF1R Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: AFS98]

Supplier: Tonbo Biosciences
20-1152-U100 20-1152-U025
20-1152-U100EA 198 EUR
20-1152-U100 20-1152-U025
Anti-CSF1R Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: AFS98]
Antibodies
The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerisation of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses,More Product Information
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