Anti-CD3e Hamster Monoclonal Antibody [clone: 145-2C11] (PerCP-Cy5.5)

Supplier: STEMCELL Technologies
60015PS 60015PS.1
STMC60015PSEA 515 EUR
STMC60015PS STMC60015PS.1
Anti-CD3e Hamster Monoclonal Antibody [clone: 145-2C11] (PerCP-Cy5.5)
Antibodies
Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD4, PE-conjugated.

  • T cells
  • T cells CD4
  • T cells Regulatory

The OKT4 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 to D4). The epitope for OKT4 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a non-polymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for human immunodeficiency virus (HIV). Binding of the OKT4 antibody to CD4 does not block HIV binding. This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Direct human CD4+ T cell isolation kit (Catalog #19662), EasySep™ human CD4+ T cell enrichment kit (Catalog #19052), EasySep™ human CD3 positive selection kit II (Catalog #17851) and EasySep™ human CD4 positive selection kit II (Catalog #17852).

Upozornení: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type: Anti-CD3e Hamster Monoclonal Antibody [clone: 145-2C11] (PerCP-Cy5.5)
Antigen: CD3e
Clonality: Monoclonal
Clone: 145-2C11
Conjugation: PerCP-Cy5.5
Epitope:
Host: Hamster
Isotype: IgG1 kappa
Reactivity: Mouse
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