Anti-CD16 Mouse Monoclonal Antibody [clone: 3G8] (FITC)

Supplier: STEMCELL Technologies
60041FI 60041FI.1
STMC60041FIEA 466 EUR
STMC60041FI STMC60041FI.1
Anti-CD16 Mouse Monoclonal Antibody [clone: 3G8] (FITC)
Antibodies
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD16, FITC-conjugated.

  • Granulocytes
  • Subsets
  • Monocytes

The 3G8 antibody reacts with CD16 (FcγRIII or low affinity IgG receptor III), a type 1 transmembrane glycoprotein belonging to the Ig superfamily. CD16 exists in two distinct isoforms: CD16a, a 50 to 65 kDa form expressed on NK cells, activated monocytes, macrophages, and placental trophoblasts, and CD16b, an ~48 kDa glycosylphosphatidylinositol (GPI)-anchored form expressed on neutrophils, basophils and eosinophils and found as at least two polymorphic variants, termed NA1 and NA2. CD16 binds weakly to the Fc region of monomeric, aggregated or complexed IgG, particularly the IgG1 and IgG3 isotypes. Binding of IgG to either CD16 isoform induces signaling pathways that modulate several types of responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release and proliferation. CD16/IgG interactions can result in non-specific labeling in antibody-based detection and cell separation experiments and the 3G8 antibody may be employed as a blocking antibody to reduce non-specific binding.

Upozornení: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type: Anti-CD16 Mouse Monoclonal Antibody [clone: 3G8] (FITC)
Antigen: CD16
Clonality: Monoclonal
Clone: 3G8
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Capuchin monkey, Chimpanzee, Common marmoset, Cotton-topped tamarin, Cynomolgus monkey, Human, Macaque, Rhesus monkey, Sooty mangabey, Squirrel monkey
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