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Image Unavailable-ENZOBMLEI1550100

D-erythro-Sphingosine ≥98% (by TLC)

Catalog Number: (ENZOBMLEI1550100)
Supplier: ENZO LIFE SCIENCES
Description: Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.
UOM: 1 * 100 mg
Image Unavailable-ENZOBMLEI2620010

7-Ethoxyresorufin ≥98%

Catalog Number: (ENZOBMLEI2620010)
Supplier: ENZO LIFE SCIENCES
Description: Cytochrome P450 substrate
UOM: 1 * 10 mg
Image Unavailable-ENZOBMLEI2560200

Metyrapone ≥99%

Catalog Number: (ENZOBMLEI2560200)
Supplier: ENZO LIFE SCIENCES
Description: Inhibits cytochrome P-450-mediated prostaglandin ω/ω-1 hydroxylase activity.
UOM: 1 * 200 mg
Image Unavailable-ENZOBMLEI2480005

HNMPA-(AM)3 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

Image Unavailable-ENZOBMLEI2790010

BAY 11-7085 ≥99%

Supplier: ENZO LIFE SCIENCES
Description: NF-kappaB inhibitor

Image Unavailable-ENZOBMLEI2340100

K-252b ≥98% (by HPLC)

Catalog Number: (ENZOBMLEI2340100)
Supplier: ENZO LIFE SCIENCES
Description: General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).
UOM: 1 * 100 µG
Image Unavailable-ENZOBMLEI2630025

Tyrphostin AG-126 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Image Unavailable-ENZOBMLEI2660005

MK-886 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES
Description: Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.

Image Unavailable-ENZOBMLEI3120005

SB216763 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.

Image Unavailable-ENZOBMLEI3200001

Sodium 4-phenylbutyrate ≥98% (by UHPLC)

Catalog Number: (ENZOBMLEI3200001)
Supplier: ENZO LIFE SCIENCES
Description: Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.
UOM: 1 * 1 g
Image Unavailable-ENZOBMLEI2850001

Radicicol ≥97%

Catalog Number: (ENZOBMLEI2850001)
Supplier: ENZO LIFE SCIENCES
Description: HSP90 inhibitor
UOM: 1 * 1 mg
Image Unavailable-ENZOBMLEI3090005

2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione ≥98% (by HPLC)

Catalog Number: (ENZOBMLEI3090005)
Supplier: ENZO LIFE SCIENCES
Description: A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.
UOM: 1 * 5 mg
Image Unavailable-ENZOBMLEI2960500

Gö 6983 ≥95% (by HPLC)

Catalog Number: (ENZOBMLEI2960500)
Supplier: ENZO LIFE SCIENCES
Description: PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50 = 7nM for PKCα and PKCβ; 6nM for PKCγ; 10nM for PKCδ; 60nM for PKCζ). The compound does not effectively inhibit PKCµ (IC50=20 µM) and therefore can be used to differentiate PKCµ from other isoforms.
UOM: 1 * 0,5 mg
Image Unavailable-ENZOBMLGP1000005

Ar231453 ≥98% (by HPLC), yellow solid

Supplier: ENZO LIFE SCIENCES
Description: GPR119 activator.

Image Unavailable-ENZOBMLFR1000100

21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]triene-3,20-dione maleate salt ≥98% (by TLC)

Catalog Number: (ENZOBMLFR1000100)
Supplier: ENZO LIFE SCIENCES
Description: Blocks lipid peroxidation
UOM: 1 * 100 mg
Image Unavailable-ENZOBMLG2290025

Chaetomellic acid A ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES
Description: Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
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