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Supplier: STEMCELL Technologies
Description: Interleukin 31 (IL-31), a four-helix bundle inflammatory cytokine, belongs to the IL-6 cytokine family which includes IL-6, oncostatin M, leukemia inhibitory factor (LIF), and cardiotrophin-1 ( Dillon <i>et al.</i>). IL-31 signals through a heterodimer composed of IL-31RA (also known as gp130-like receptor or GPL) and the oncostatin-M receptor (OSMR), both of which are expressed on monocytes (Diveu <i>et al.</i>; Ghilardi <i>et al.</i>), epithelial cells (Ip <i>et al.</i>), and keratinocytes (Kato <i>et al.</i>). Signaling through the GPL/OSMR complex activates the JAK/STAT, RAS/ERK, and PI3K/AKT signaling pathways, resulting in the downstream activation of STAT1, STAT3, and STAT5 transcription factors (Cornelissen <i>et al.</i>; Dambacher <i>et al.</i>; Dillon <i>et al.</i>; Ip <i>et al.</i>). IL-31 responses have been associated with allergic responses and inflammatory skin diseases including atopic dermatitis (Cornelissen <i>et al.</i>; Gangemi <i>et al.</i>).

Catalog Number: (STMC04435)
Supplier: STEMCELL Technologies
Description: Methylcellulose-based medium with recombinant cytokines for human cells. 1x100ml bottle.
UOM: 1 * 100 mL


Supplier: STEMCELL Technologies
Description: Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, PE-conjugated.

Catalog Number: (STMC100-0243)
Supplier: STEMCELL Technologies
Description: Mouse monoclonal IgG1 antibody against human, mouse CD105 (endoglin).
UOM: 1 * 25 Tests


Supplier: STEMCELL Technologies
Description: Column-free immunomagnetic positive selection of human CD56+ cells for HLA analysis

Supplier: STEMCELL Technologies
Description: Column-free immunomagnetic positive selection of human CD33+ and CD66b+ cells for HLA analysis.

Catalog Number: (STMC100-0031)
Supplier: STEMCELL Technologies
Description: Immunomagnetic positive selection of particle-free human cells labeled with APC-conjugated antibodies.
UOM: 1 * 1 KIT


Supplier: STEMCELL Technologies
Description: Immunomagnetic positive selection of particle-free CD45+ leukocytes from primary human tissues and tumors.

Supplier: STEMCELL Technologies
Description: Immunomagnetic positive selection of any cells labeled with biotinylated antibodies.

Catalog Number: (STMC17865)
Supplier: STEMCELL Technologies
Description: Immunomagnetic positive selection of human central and effector memory CD4+ T cells.
UOM: 1 * 1 KIT


Catalog Number: (STMC17869)
Supplier: STEMCELL Technologies
Description: Immunomagnetic positive selection of human central and effector memory CD8+ T cells.
UOM: 1 * 1 KIT


Supplier: STEMCELL Technologies
Description: Column-free immunomagnetic positive selection of human CD4+ cells for HLA analysis.

Supplier: STEMCELL Technologies
Description: Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford <i>et al.</i>). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann and Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford <i>et al.</i>).

Supplier: STEMCELL Technologies
Description: For detection and measurement of mouse interferon-gamma.

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Catalog Number: (STMC100-0923)
Supplier: STEMCELL Technologies
Description: For detection of active caspase-3 in mammalian cells undergoing apoptosis - 100 tests.
UOM: 1 * 100 items


Supplier: STEMCELL Technologies
Description: For digestion of the extracellular matrix of cartilage.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at +43 1 97002 - 0.
Dual use goods can only be delivered within the European Union.
Dual use goods can only be delivered within the European Union.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at +43 1 97002 - 0.
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