You Searched For: STEMCELL Technologies

Supplier: STEMCELL Technologies

Description: Vascular endothelial growth factor D (VEGF-D) is a member of the VEGF/platelet-derived growth factor (PDGF) family of proteins. VEGF-D is a potent angiogenic factor and promotes lymphangiogenesis, endothelial cell growth and survival, and can affect blood vessel permeability. VEGF-D is expressed in the lung, heart, small intestine, fetal lung, and at lower levels in the pancreas, colon, and skeletal muscle (Otrock <i>et al.</i>; Roy <i>et al.</i>; Stacker <i>et al.</i>; Yamada <i>et al.</i>). VEGF-D is a ligand for VEGF receptors 2 (Flk1) and 3 (Flt4) (Baldwin <i>et al.</i>). VEFGR-3 is highly expressed in lymphatic endothelial cells and is essential for their growth and differentiation (Otrock <i>et al.</i>; Roy <i>et al.</i>). Binding of VEGF-D to neuropilins contributes to VEGFR-3 signaling during lymphangiogenesis, whereas binding to integrin α9β1 promotes endothelial cell adhesion and migration (Roy <i>et al.</i>; Otrock <i>et al.</i>). During embryogenesis, VEGF-D also plays a role in the formation of the venous and lymphatic systems.

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Supplier: STEMCELL Technologies

Description: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit <i>et al.</i>), the activation of metalloproteases that cleave VCAM-1 (Levesque <i>et al.</i>), and the release of norepinephrine from the sympathetic nervous system (Katayama <i>et al.</i>), leading to the release or mobilisation of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways. This product is animal component-free.

Catalog Number: (STMC05791)

Supplier: STEMCELL Technologies

Description: Serum-free neurophysiological basal medium for improved neuronal function.

UOM: 1 * 500 mL

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Catalog Number: (STMC07400)

Supplier: STEMCELL Technologies

Description: 0,25% porcine trypsin in citrate saline solution for the detachment of adherent cells.

UOM: 1 * 100 mL

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Catalog Number: (STMC100-0900)

Supplier: STEMCELL Technologies

Description: For differentiation of human ES or iPS cells to megakaryocytes and platelets.

UOM: 1 * 1 KIT

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Catalog Number: (STMC100-0384)

Supplier: STEMCELL Technologies

Description: Culture medium to initiate organoids from primary liver tissue.

UOM: 1 * 1 KIT

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Supplier: STEMCELL Technologies

Description: Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick <i>et al.</i>). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata <i>et al.</i>). This product is animal component-free.

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Catalog Number: (STMC100-0854)

Supplier: STEMCELL Technologies

Description: Fluorescent dye conjugates for detection of F-actin in cell culture experiments - 300 tests.

UOM: 1 * 300 Tests

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Supplier: STEMCELL Technologies

Description: Interleukin 7 (IL-7) is a member of the type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström <i>et al.</i>). IL-7 binds to a receptor composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette and Surh), and provides signals to promote survival, proliferation, and differentiation during B cell development (Clark <i>et al.</i>; Corfe and Paige).

Supplier: STEMCELL Technologies

Description: Biopreservation reagent for cells and tissues.

Catalog Number: (STMC01350)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal antibody to human erythropoietin.

UOM: 1 * 0,1 mL

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Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, rhesus, sooty mangabey CD123 (IL-3Rα), FITC-conjugated.

Supplier: STEMCELL Technologies

Description: For depletion of red blood cells from fresh blood samples and isolation of nucleated cells.

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD45, FITC-conjugated.

Supplier: STEMCELL Technologies

Description: Immunomagnetic positive selection of human CD14+ cells (e.g. monocytes).

Supplier: STEMCELL Technologies

Description: (C3H x BALB/c) F1 hybrid monoclonal IgG2a antibody against mouse NK1.1 (CD161).