You Searched For: 8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde

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8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde

Supplier: Apollo Scientific

Description: 8-Phenyl-1,4-dioxaspiro[4.5]decane-8-carbaldehyde

WYE-125132 ≥99% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Description: Highly potent, ATP-competitive, and specific mTOR kinase inhibitor. Antiproliferative.

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WYE-125132 ≥98%, crystalline solid

Supplier: Cayman Chemical

Description: WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.